Tryptophan is an essential amino acid that must be supplied to the human body. Tryptophan is a source of very important regulatory compounds such as tryptamine, serotonin and melatonin. Serotonin is a neurotransmitter in the brain responsible for positive mood. St. John’s wort has an effective aid for the treating of the mild to moderate depression and related symptoms such as anxiety or insomnia. St. John’s wort extract is widely recognized for its positive, supportive effects on mental and emotional function, this activity is mainly contribute to its hypericin content. L-glycine is an amino acid used by the body to synthesize neurotransmitters. Taking L- glycine before bedtime might also reduce feelings of tiredness the following day after a shortened night of sleep. Magnesium has many functions in the body. Among other things, it contributes to the proper functioning of the nervous system and reduces the feeling of tiredness and fatigue. Vitamin C, like magnesium, is involved in many processes in the body. It contributes to the proper energy metabolism, proper functioning of the nervous system and psychological functions. Vitamin C protects cells from the oxidative stress.